Fred Ledley: search on Z-Library

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1

Somatic gene therapy for human disease: a problem of eugenics?

Journal:

Trends in Genetics

Year:

1987

Language:

english

File:

PDF, 463 KB

english, 1987

2

Profitability of Large Pharmaceutical Companies Compared With Other Large Public Companies

Ledley, Fred D., McCoy, Sarah Shonka, Vaughan, Gregory, Cleary, Ekaterina Galkina

Journal:

Year:

2020

File:

PDF, 416 KB

2020

3

Profitability of Large Pharmaceutical Companies Compared With Other Large Public Companies

Ledley, Fred D., McCoy, Sarah Shonka, Vaughan, Gregory, Cleary, Ekaterina Galkina

Journal:

Obstetric and Gynecologic Survey

Year:

2020

File:

PDF, 74 KB

2020

4

Landscape of Innovation for Cardiovascular Pharmaceuticals: From Basic Science to New Molecular Entities

Beierlein, Jennifer M., McNamee, Laura M., Walsh, Michael J., Kaitin, Kenneth I., DiMasi, Joseph A., Ledley, Fred D.

Journal:

Clinical Therapeutics

Year:

2017

Language:

english

File:

PDF, 25.10 MB

english, 2017

5

Nonviral Gene Therapy: The Promise of Genes as Pharmaceutical Products

Ledley, Fred D.

Journal:

Human Gene Therapy

Year:

1995

Language:

english

File:

PDF, 689 KB

english, 1995

6

Making the biotech IPO work

McNamee, Laura, Ledley, Fred

Journal:

Nature Biotechnology

Year:

2013

Language:

english

File:

PDF, 264 KB

english, 2013

7

Evolution and the Human Tail

Ledley, Fred D.

Journal:

Boston Medical and Surgical Journal

Year:

1982

Language:

english

File:

PDF, 1.38 MB

english, 1982

8

Methods Used to Assess Pharmaceutical Research and Development Costs

Ledley, Fred D.

Journal:

JAMA Internal Medicine

Year:

2018

Language:

english

File:

PDF, 91 KB

english, 2018

9

The subcutaneous spleen: A new model for hepatocellular transplantation

Mary L. Brandt, Jordan W. Eckert, Humberto Soriano, Carla Buerkle, Fred Ledley, William J. Pokomy

Journal:

Journal of Pediatric Surgery

Year:

1993

Language:

english

File:

PDF, 165 KB

english, 1993

10

Thyrotropin interactions with human fat cell membrane preparations and the finding of a soluble thyrotropin binding component

Brian R. Mullin, George Lee, Fred D. Ledley, Roger J. Winand, Leonard D. Kohn

Journal:

Biochemical and Biophysical Research Communications

Year:

1976

Language:

english

File:

PDF, 381 KB

english, 1976

11

In Vivo Gene Transfer into Rabbit Thyroid Follicular Cells by Direct DNA Injection

Sikes, Michael L., O'Malley, Bert W., Finegold, Milton J., Ledley, Fred D.

Journal:

Human Gene Therapy

Year:

1994

Language:

english

File:

PDF, 10.29 MB

english, 1994

12

Gene Transfer to Synovial Cells by Intra-Articular Administration of Plasmid DNA

Yovandich, Jason, O'malley, Bert, Sikes, Michael, Ledley, Fred D.

Journal:

Human Gene Therapy

Year:

1995

Language:

english

File:

PDF, 12.63 MB

english, 1995

13

Therapeutic Promise of Molecular Genetics.

Ledley, Fred D.

Journal:

The Journal of Investigative Dermatology

Year:

1994

Language:

english

File:

PDF, 4.54 MB

english, 1994

14

Book ReviewGenetics in Clinical Oncology

Ledley, Fred D.

Journal:

Boston Medical and Surgical Journal

Year:

1986

File:

PDF, 437 KB

1986

15

Book ReviewThe Consequences of Chromosome Imbalance: Principles, mechanisms, and models

Ledley, Fred D.

Journal:

Boston Medical and Surgical Journal

Year:

1986

File:

PDF, 217 KB

1986

16

Perspectives on methylmalonic acidemia resulting from molecular cloning of methylmalonyl CoA mutase

Journal:

Year:

1990

Language:

english

File:

PDF, 758 KB

english, 1990

17

Ketoacidotic crisis as a presentation of mild (“benign”) methylmalonic acidemia

Stuart K. Shapira, Fred D. Ledley, David S. Rosenblatt, Harvey L. Levy

Journal:

The Journal of Pediatrics

Year:

1991

Language:

english

File:

PDF, 523 KB

english, 1991

18

Cloning of full-length methylmalonyl-CoA mutase from a cDNA library using the polymerase chain reaction

Jansen, Ruud, Kalousek, Frantisek, Fenton, Wayne A., Rosenberg, Leon E., Ledley, Fred D.

Journal:

Year:

1989

Language:

english

File:

PDF, 1014 KB

english, 1989

19

Mapping of the l-methylmalonyl-CoA mutase gene to mouse chromosome 17

Sertić, Jadranka, Vincek, Vladimir, Ledley, Fred D., Figueroa, Felipe, Klein, Jan

Journal:

Year:

1990

Language:

english

File:

PDF, 1.13 MB

english, 1990

20

Retroviral Gene Transfer into the Intestinal Epithelium

Lau, Chantal, Soriano, Humberto E., Ledley, Fred D., Finegold, Milton J., Wolfe, John H., Birkenmeier, Edward H., Henning, Susan J.

Journal:

Human Gene Therapy

Year:

1995

Language:

english

File:

PDF, 4.20 MB

english, 1995

21

What does the current biotech stock market value?

McNamee, Laura, Ledley, Fred

Journal:

Nature Biotechnology

Year:

2015

Language:

english

File:

PDF, 300 KB

english, 2015

22

A consumer charter for genomic services

Journal:

Nature Biotechnology

Year:

2002

Language:

english

File:

PDF, 46 KB

english, 2002

23

Pharmaceutical Approach to Somatic Gene Therapy

Journal:

Pharmaceutical Research

Year:

1996

File:

PDF, 4.34 MB

1996

24

Correlation between polymorphic DNA haplotypes at phenylalanine hydroxylase locus and clinical phenotypes of phenylketonuria

Flemming Güttler, Fred D. Ledley, Alan S. Lidsky, Anthony G. DiLella, Susan E. Sullivan, Savio L.C. Woo

Journal:

The Journal of Pediatrics

Year:

1987

Language:

english

File:

PDF, 363 KB

english, 1987

25

Distinguishing Genetics and Eugenics on the Basis of Fairness

Journal:

Journal of Medical Ethics

Year:

1994

Language:

english

File:

PDF, 1.61 MB

english, 1994

26

Non-viral gene therapy

Journal:

Current Opinion in Biotechnology

Year:

1994

Language:

english

File:

PDF, 1.14 MB

english, 1994

27

Phenotype of disease in three patients with identical mutations in methylmalonyl CoA mutase

Ana Maria Crane, Laura S. Martin, David Valle, Fred D. Ledley

Journal:

Year:

1992

Language:

english

File:

PDF, 736 KB

english, 1992

28

Structure and Expression of Human Dihydropteridine Reductase

Jean Lockyer, Richard G. Cook, Sheldon Milstien, Seymour Kaufman, Savio L. C. Woo and Fred D. Ledley

Journal:

Proceedings of the National Academy of Sciences

Year:

1987

Language:

english

File:

PDF, 1.11 MB

english, 1987

29

Multicompartment, Numerical Model of Cellular Events in the Pharmacokinetics of Gene Therapies

Ledley, Tamara Shapiro, Ledley, Fred D.

Journal:

Human Gene Therapy

Year:

1994

Language:

english

File:

PDF, 5.59 MB

english, 1994

30

NIH funding for research underlying new cancer therapies

Cleary, Ekaterina Galkina, Ledley, Fred D

Journal:

The Lancet Oncology

Year:

2020

File:

PDF, 374 KB

2020

31

Propionate metabolism in cultured human cells after overexpression of recombinant methylmalonyl CoA mutase: Implications for somatic gene therapy

Michael Wilkemeyer, Jozsef Stankovics, Thomas Foy, Fred D. Ledley

Journal:

Somatic Cell and Molecular Genetics

Year:

1992

Language:

english

File:

PDF, 1.31 MB

english, 1992

32

Molecular structure and polymorphic map of the human phenylalanine hydroxylase gene

DiLella, Anthony G., Kwok, Simon C. M., Ledley, Fred D., Marvit, Joshua, Woo, Savio L. C.

Journal:

Year:

1986

Language:

english

File:

PDF, 1.73 MB

english, 1986

33

Molecular Basis of Phenylketonuria and Recombinant DNA Strategies for Its Therapy

Woo, Savio L. C., DiLella, Anthony G., Marvit, J., Ledley, Fred D.

Journal:

Year:

1987

File:

PDF, 972 KB

1987

34

Why pharmacogenomics? Why now?

Housman, David, Ledley, Fred D.

Journal:

Nature Biotechnology

Year:

1998

File:

PDF, 326 KB

1998

35

Correction of methylmalonyl-CoA mutase deficiency inMutofibroblasts and constitution of gene expression in primary human hepatocytes by retroviral-mediated gene transfer

Takako Sawada, Fred D. Ledley

Journal:

Somatic Cell and Molecular Genetics

Year:

1992

Language:

english

File:

PDF, 1015 KB

english, 1992

36

Replies

Journal:

The Journal of Pediatrics

Year:

1989

Language:

english

File:

PDF, 224 KB

english, 1989

37

Complete cDNA sequence and chromosomal localization of mouse α1-antitrypsin

Sifers, Richard N., Ledley, Fred D., Reed-Fourquet, Lori, Ledbetter, David H., Ledbetter, Susan A., Woo, Savio L.C.

Journal:

Year:

1990

Language:

english

File:

PDF, 600 KB

english, 1990

38

Hepatocellular Transplantation in Acute Hepatic Failure and Targeting Genetic Markers to Hepatic Cells. Baylor College of Medicine

Ledley, Fred David, Woo, Savio L. C., Ferry, George D., Whisennand, Hartwell H., Brandt, Mary L., Darlington, Gretchen J., Demmler, Gail J., Finegold, Milton J., Pokorny, William J., Rosenblatt, Howar

Journal:

Human Gene Therapy

Year:

1991

Language:

english

File:

PDF, 4.86 MB

english, 1991

39

Book ReviewPerinatal Genetics: Diagnosis and treatment

Ledley, Fred D.

Journal:

Boston Medical and Surgical Journal

Year:

1987

File:

PDF, 208 KB

1987

40

Book Review Backdoor to Eugenics By Troy Duster. 201 pp. New York, Routledge, 1990. $39.95 (cloth); $14.95 (paper).

Ledley, Fred D.

Journal:

Boston Medical and Surgical Journal

Year:

1991

File:

PDF, 217 KB

1991

41

Why pharmacogenomics? Why now?

Housman, David, Ledley, Fred D.

Journal:

Nature Biotechnology

Year:

1998

Language:

english

File:

PDF, 178 KB

english, 1998

42

DNA-and viral-mediated gene transfer in follicular cells: Progress toward gene therapy of the thyroid

Bert W. O'Malley Jr., Fred D. Ledley

Journal:

The Laryngoscope

Year:

1993

File:

PDF, 1.12 MB

1993

43

Molecular Cloning of L-methylmalonyl-CoA Mutase: Gene Transfer and Analysis of mut Cell Lines

Fred D. Ledley, Michele Lumetta, Phi Nga Nguyen, J. Fred Kolhouse and Robert H. Allen

Journal:

Proceedings of the National Academy of Sciences

Year:

1988

Language:

english

File:

PDF, 765 KB

english, 1988

44

Patterns of Innovation in Alzheimer’s Disease Drug Development: A Strategic Assessment Based on Technological Maturity

Beierlein, Jennifer M., McNamee, Laura M., Walsh, Michael J., Ledley, Fred D.

Journal:

Clinical Therapeutics

Year:

2015

Language:

english

File:

PDF, 441 KB

english, 2015

45

Book ReviewThe Growth of Biological Thought: Diversity, evolution and inheritance

Ledley, Fred D.

Journal:

Boston Medical and Surgical Journal

Year:

1983

File:

PDF, 440 KB

1983

46

Therapeutic Promise of Molecular Genetics

Journal:

The Journal of Investigative Dermatology

Year:

1994

Language:

english

File:

PDF, 737 KB

english, 1994

47

The Physician-Scientists Role in Medical Research and the Mythology of Intellectual Tradition

Ledley, Fred D.

Journal:

Perspectives in Biology and Medicine

Year:

1991

File:

PDF, 763 KB

1991

48

10.1038/11614

Ledley, Fred D.

Journal:

Nature Biotechnology

Year:

1999

Language:

english

File:

PDF, 43 KB

english, 1999

49

Computer analysis of ultrasoundcardiograms

Fred D. Ledley, James B. Wilson

Journal:

Computers in Biology and Medicine

Year:

1974

Language:

english

File:

PDF, 8.67 MB

english, 1974

50

Separation of the glycoprotein and ganglioside components of thyrotropin receptor activity in plasma membranes

Maria F. Meldolesi, Peter H. Fishman, Salvatore M. Aloj, Fred D. Ledley, George Lee, Roy M. Bradley, Roscoe O. Brady, Leonard D. Kohn

Journal:

Biochemical and Biophysical Research Communications

Year:

1977

Language:

english

File:

PDF, 450 KB

english, 1977

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